DNA methylation profile is a quantitative measure of biological aging in children
نویسندگان
چکیده
منابع مشابه
DNA methylation is a reversible biological signal.
The pattern of DNA methylation plays an important role in regulating different genome functions. To test the hypothesis that DNA methylation is a reversible biochemical process, we purified a DNA demethylase from human cells that catalyzes the cleavage of a methyl residue from 5-methyl cytosine and its release as methanol. We show that similar to DNA methyltransferase, DNA demethylase shows CpG...
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Seed deterioration is loss of seed quality, viability and vigor due to effect of adverse environmental factors. Many of our crops are reproduced through seeds, and throughout the world large quantities are produced, stored and transported. Seed ageing during storage may cause retardation of field establishment, and may eventually result in seedling abnormalities or even failure of emergence. Du...
متن کاملAging in Orthodox Seeds is a Problem
Seed deterioration is loss of seed quality, viability and vigor due to effect of adverse environmental factors. Many of our crops are reproduced through seeds, and throughout the world large quantities are produced, stored and transported. Seed ageing during storage may cause retardation of field establishment, and may eventually result in seedling abnormalities or even failure of emergence. Du...
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BACKGROUND Adiposity is a risk factor for type 2 diabetes and cardiovascular disease, suggesting an important role for adipose tissue in the development of these conditions. The epigenetic underpinnings of adiposity are not well understood, and studies of DNA methylation in relation to adiposity have rarely focused on target adipose tissue. Objectives were to evaluate whether genome-wide DNA me...
متن کاملA quantitative HpaII-PCR assay to measure methylation of DNA from a small number of cells.
Methylation-sensitive restriction enzymes and Southern blot analysis are commonly used to assay for DNA methylation, usually requiring DNA from about 105 cells. However sensitivity adequate for only a few hundred cells is needed in many cases, for example, the study of DNA methylation changes in germ cells or pre-implantation embryos. We earlier reported a sensitive PCR assay using primers that...
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ژورنال
عنوان ژورنال: Aging
سال: 2019
ISSN: 1945-4589
DOI: 10.18632/aging.102399